Inflammatory Biomarkers Status and Liver Enzymes Among Hyperuricemia Patients in Gaza Strip

Background: The significance of hyperuricemia as a risk factor of incidence of myocardial infarction has been a debate for recent decades. However, Hyperuricemia has been shown to predict the development of heart failure, elevated in weight, hyper-insulinemia of secondary hypertension. Several studies have demonstrated that hyperuricemia is also associated with elevated inflammatory biomarkers levels and development of nonalcoholic fatty liver disease (NAFLD). The aims of the present study were to assess inflammatory biomarkers status and liver enzymes among hyperuricemia patients in Gaza Strip.

Materials and Methods: A case-control study has been conducted on 70 subjects with hyperuricemia and 70 healthy subjects with normal uric acid as control aged between 41-70 years. Erythrocyte sedimentation rate (ESR), C - reactive protein (CRP), complement 3 (C3), ferritin, fibrinogen and liver enzymes were measured.

Results: The results pointed out the average levels of ESR, CRP, C3, ferritin, fibrinogen AST and ALT were significantly higher in cases compared to controls. Pearson correlation showed that a positive significant correlation between uric acid and CRP (r = 0.656, P < 0.001), Fibrinogen (r = 0.784, P < 0.001), Ferritin (r = 0.939, P < 0.001), ESR (r = 0.89, P < 0.001), ALT (r = 0.886, P < 0.001), AST (r = 0.844, P < 0.001).

Conclusion: Hyperuricemia should be treated because it induces an inflammatory reaction and increases liver enzymess disorder. both hyperuricemia and dyslipidemia will enhance the risk for heart failure. In brief, new strategic management must be developed in order to decrease hyperuricemia among adult.

Keywords: Inflammatory biomarkers; Liver enzymes; Hyperuricemia; Gaza Strip