Fournier’s Gangrene without Organ Perforation Following Docetaxel: A Rare Urological Emergency Occurrence in a Patient with Metastatic Prostate Cancer

Fournier’s gangrene (FG) which is known as necrotizing fasciitis of urogenital regions, is a rapidly progressive polybacterial infection, involving the subcutaneous and deep fascias in the urogenital region. The most common reasons are localized infections caused by colorectal, genitourinary and dermatological factors. On the other hand, its development following chemotherapy application is rare. Emergency and repetitive radical surgical debridement, wound drainage and parenteral antibiotherapy are mandatory because of high mortality rates in FG. In the literature, there is no reported case of FG in metastatic prostate cancer following docetaxel. We present a rare case of FG without visceral organ perforation, caused by docetaxel in a 72-year-old man. A similar case has not been reported. In literature, there are only a few known FG cases associated with bevacizumabrelated rectal and small intestinal perforation in rectal cancer.

Keywords: Docetaxel; Emergency surgical debridement; Fournier’s gangrene; Metastatic prostate cancer