Review Article
Vitrification and its impact on oocyte structures. A review
Alma López1, Miguel Betancourt2 and Fahiel Casillas3 *
1PHD in Biological and Health Sciences, Mexico
2Department of Health Sciences, Mexico
3Department of Biology of Reproduction, Mexico
Fahiel Casillas, Autonomous Metropolitan University- Iztapalapa Unit, CDMX, Mexico.
Received Date: December 12, 2019; Published Date: January 17, 2020
Abstract
The vitrification of oocytes and embryos produces structural damage caused by the cytotoxicity of the cryoprotective agents (CPAs). Some of these damages occur in the cell plasma membrane, cytoskeleton and genetic material, which might result in the formation of aneuploidies. The toxicity produced by the use of CPAs during vitrification can cause alterations in microfilaments (MF), microtubules (MT) and chromatin (CR), affecting not only cell viability, maturation, fertilization and embryonic development (ED), but also the genetic integrity that will result in the formation of aneuploidies. The latter can result in spontaneous abortions and/or the absence of a term pregnancy, and if an opposite case arises, the birth of offspring with chromosomal aberrations will affect the organism development.
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Alma López, Miguel Betancourt, Fahiel Casillas. Vitrification and its impact on Oocyte Structures. A Review. Arch Biomed Eng & Biotechnol. 3(4): 2020. ABEB.MS.ID.000568.
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