Gene Associated and Risk Factor of HPV Wharts : A Review Article

Introduction : HPV can infect basal epithelial cells of the skin or deep tissue and are categorized as either skin type or mucosal type. This skin type is epidermotropic and infects the surface of the keratinized skin, targeting the skin of the hands and feet. The type of mucosa that is infected is the lining of the mouth, throat, respiratory, or anogenital tract epithelium. The direct correlation between the number of sexual partners and the presence of HPV was shown to be independent of other risk factors such as age, race or use of oral contraceptives as well. Several genes and risk factors have been associated with genital HPV infection. The purpose of this review is to determine the genes and risk factors for Wharts. Discussion : Detection of various genital HPV as many as 28 types that have been identified so far can use various methods. Identification of viral DNA or RNA by various hybridization techniques. Time to analyze the results is also very important to know the validity of the different HPV techniques, the sensitivity, specificity, and the spectrum of HPV types detected. Southern Blot hybridization is still used as the standard for DNA identification of various types of HPV. However, between 5000 and 50 000 copies of HPV DNA must be present in a clinical sample to be detected. Conclusion : The seroprevalence of other types, including 18, 31, 33, 39, 58, and 59, ranging from 9% to 23%. In addition to VLP, HPV DNA is also most common in women under 25 years of age, prevalence tends to peak in women over 25 years of age using HPV antibodies. Number of sexual partners was recognized as an independent risk factor for genital HPV infection in patients with immunosuppression will also be a risk factor for HPV infection, for example in patients with autoimmune, HIV infection and organ transplantation.

Keywords: Gene; Risk Factor; HPV infection; Wharts disease