Antiviral Activity of Extracts of <i>Plocamium
Brasiliense</i> and<i> Plocamium Cartilagineum</i> at in Vitro
Replication of Human Immunodeficiency Virus Type 1

Abdul Kader Mohiuddin*; Sofian S Mohamed 1; Inass A Sadawe; Nisreen H Meiqal; Abdulathim A Alshoushan

Review Article

Antiviral Activity of Extracts of Plocamium Brasiliense and Plocamium Cartilagineum at in Vitro Replication of Human Immunodeficiency Virus Type 1

Ingrid De Barcelos Oliveira^1,4,5, Rainiomar Raimundo Fonseca^2,4, Claudio Cesar Cirne-Santos^1,3,4, Carolinede Souza Barros^1,3,4, Valeria Launeville Teixeira^2,3,4, Izabel Christina Nunes de Palmer Paixao^1,3*

¹Department of Celular and Molecular Biology, Laboratory of Molecular Virology, Federal Fluminense University, Brazil

²Department of Marine Biology, Laboratory of Marine Natural Products, Institute of Biology, Federal Fluminense University, Brazil

³Post-graduate Program in Science and Biotecnology, Federal Fluminense University, Brazil

⁴Post-graduate Program in Chemistry, Institute of Chemistry, Federal Fluminense University, Brazil

Corresponding Author

Received Date:September 23, 2019; Published Date:September 30, 2019

Abstract

The marine macroalgae Plocamium brasiliense and P. cartilagineum are species characterized by the production of halogenated metabolites. For the present study, algae were collected from the coast of Rio de Janeiro, Brazil and the Cape Verde Archipelago, in the African continent. The raw extracts of the algae were prepared in different solvents exhaustively and fractionated for later isolation and structural elucidation of the major substances to compare the chemical profile of the two species of red algae. The hydroalcoholic extracts of both species showed antiviral activity against the HIV-1 virus and were the least cytotoxic. The dichloromethane extract of the P.brasiliense macroalgae had the lowest antiviral effect among the others tested. Virucidal activity, however, was not observed. Based on NMR, IR and literature data, it was found that the antiviral result was attributed to the sulfated polysaccharides in the red macroalgae. Both macroalgae show potential to be exploited by marine biotechnology, based on the results found in this work.

Keywords:HIV-1; Seaweed; P. cartilagineum; Halogenated monoterpenes; Allelopathy

Article Details

Citation

Izabel Christina Nunes de Palmer Paixao, Ingrid De Barcelos Oliveira, Rainiomar Raimundo Fonseca, Claudio Cesar Cirne-Santos, et al. Antiviral Activity of Extracts of Plocamium brasiliense and P. cartilagineum at in Vitro Replication of Human Immunodeficiency Virus Type 1. Arch Biomed Eng & Biotechnol. 3(1): 2019. ABEB.MS.ID.000552.