Lp (A) and Aortic Stenosis

Scott W Shurmur

Case Report

Lp (A) and Aortic Stenosis

Scott W Shurmur*

Department of Internal Medicine, University of Texas Tech Health Sciences Center, USA

Corresponding Author

Received Date: April 20, 2020; Published Date: April 27, 2020

Abstract

Lipoprotein (a), commonly called Lp “little a”, is composed of an LDL-like particle, with an apolipoprotein B component covalently bound to apo (a). The structure of the apo (a) portion is somewhat similar to plasminogen, though number and repetition of the “Kringle” portions differs [1]. The atherogenicity of Lp (a) is increasingly appreciated. Recent genetic study confirms its strong association with clinical atherosclerosis. Additionally, some iso form of Lp (a) are strongly associated with calcific aortic stenosis (Figure 1).