The Interleukin-1β (-511T/C) is Associated with Ulcerative Colitis
1Department of Cell Biology and Genetics, Federal University of Rio Grande do Norte, Brazil
2Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Brazil
3Department of Gastroenterology, University Hospital, Federal University of Pernambuco, Brazil
4Department of Proctology, Barão de Lucena Hospital, Brazil
5Department of Surgery, University Hospital, Federal University of Pernambuco, Brazil
6Departament of Pathology, Federal University of Pernambuco, Brazilian
Received Date: August 21, 2018; Published Date: September 04, 2018
Purpose: Inflammatory bowel disease (IBD) is a group of illnesses whose primary manifestation is inflammation. The most common typical phenotypes are ulcerative colitis (UC) and Crohn’s disease (CD). Although the precise etiology remains obscure, several reports have indicated that dysfunction of the mucosal immune system play an important role in its pathogenesis. This study aimed to analyzing the genes polymorphisms of immune response in Brazilian patients with IBD.
Methods and results: 95 patients were analyzed for the caspase activation and recruitment domains 15/ NOD like receptor 2 (CARD15/NOD2) (rs2066844 and rs2066845), NOD like receptor – (NLRP1) (rs12150220), NLRP3 (rs35829419) and interleukin (IL)-1 (rs16944) genes polymorphisms. The anatomic-clinical form of CD predominant was both, fistulizing and inflammatory each (35.18%), followed by structuring (27.77%) and 1.85% structuring and fistulizing in the same patients. 91 healthy subjects composed the control group. The statistical analysis was performed using R program. NOD like receptor pyrin domain containing 1 and 3 and caspase activation and recruitment domains 15/ NOD like receptor 2 genes R702W and G908R variants were not associated to inflammatory bowel disease susceptibility. We found that AG genotype of interleukin-1beta was associated with the development of UC.
Conclusion: Our findings suggest that the IL-1 single nucleotide polymorphism is involved with UC and may be contributing to pathogenesis in Brazilian population.
Keywords: Inflammasome; Interleukin; Inflammatory bowel disease; Single nucleotide Polymorphism