The Potential of Pyrogallol as a Possible Antimalarial Drug Candidate
Received Date: August 18, 2020; Published Date: October 05, 2020
Pyrogallol is a phenolic compound naturally found in oak, hardwood plants and many fruits such as apricot, avocado and gall. This compound possesses antibacterial, antipsoriatic and antifungal properties. However, the oxidative properties of pyrogallol have been encouraging numerous researches into the potential health hazards of its consumption. Nevertheless, the oxidising agent could be used for the treatment of some diseases such as malaria. According to previous studies, some antimalarial drugs such as primaquine, chloroquine and derivatives of artemisinin have the capability to kill the parasites through the generation of oxidative stress by the free radicals they generate. In this review, the potential of pyrogallol as an antimalarial drug candidate will be discussed, focusing on the biological activities as well as the toxicological effects it has on human health.
Keywords:Pyrogallol, antimalarial drugs, oxidizing agents.
Abbreviations: G6PD: Glucose-6-phosphate dehydrogenase; P. falciparum: Plasmodium falciparum; ACTs: Artemisinin-based combination therapy; O2: Oxygen; ONOO: Peroxide Nitrite; H2O2: Hydrogen peroxide; OH: Hydroxyradical; ROS: Reactive oxygen species; Cu2+: Cupric ion; Fe3+: Ferric iron or iron (III); Mn2+: Manganese; Co2: Carbon dioxide; Fe2: Ferrous or iron (II); NPs: Nanoparticles