Comparative Analysis of Risk Factors for Liver Cirrhosis in the World
Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Russia
Received Date: November 23, 2021; Published Date:December 14, 2021
Objective: To investigate risk factors for liver cirrhosis in two groups of countries of the world with the maximum and minimum burden of liver
Materials and Methods: A comparative analysis of the risk factors and disease burden of several NCDs in 2004 (GBD 2004) was performed using the Mann-Whitney U test in two groups of countries of the world, 21 countries in each group.
Results: In accordance with the set goal, in our studies it was found that in group 1 of countries in comparison with group 2 of countries, the burden of Cirrhosis of the liver is 12 times higher (p≤0,001). The burden of comorbid liver cirrhosis diseases - alcoholism and cardiovascular disease was also 2 times higher in group 1 of countries in comparison with group 2 of countries (p≤0, 001). The burden of diabetes was not statistically significant between groups 1 and 2 countries. Major risk factors for liver cirrhosis - The burden of viral hepatitis B and C did not differ statistically between groups 1 and 2. Consumption levels of food, including animal fats, red meat, the energy of animal products and total energy was on average 1.5 - 2 times higher in group 2 countries with a low burden of liver cirrhosis and comorbid diseases (p≤0.003). Consumption of all types of alcoholic beverages: pure alcohol, spirits, wine and beer did not differ statistically between the two study groups of countries (p = 0.7).
Conclusion: The results obtained do not allow us to draw a conclusion about the risk factors for liver cirrhosis in this study. Further research on risk factors for liver cirrhosis is needed.
Keywords: Cirrhosis of eternity; Cardiovascular diseases; Diabetes mellitus; Alcoholism; Risk factors; Levels of alcohol, Food consumption
Abbreviations:AB: Alcoholic Beverage; AP: Animal Products; BMI: Body Mass Index; BP: Blood Pressure; CAB: Alcoholic Beverage Consumption;CD: Communicable Maternal, Perinatal Diseases; Cho: Blood Cholesterol; CL: Consumption Level of Selected Foods; CHD: Coronary Heart Disease; CV: Cereals and Vegetables; CVD: Cardiovascular Diseases; DALY: The Disability-Adjusted Life Year; DRD2 and DRD3: Genes Encode Type 2 and 3 Dopamine Receptors; EEI: Ecological Efficiency Index; FAO: Food and Agriculture Organization of the United Nations; FS: Fruits and Sweeteners; ICD-10: Codes - Is the 10th Revision of the International Statistical Classification of Diseases; GBD: Global Burden Diseases; GDP: Domestic Gross Product; Glu: Blood Glucose; HPI: Happiness Index; IHD: Index of Human Development; LE: Life Expectancy for Men and Women; LPA: Low Physical Activity, LMA: Linear Multiple Regression Analysis; M: Male; NS: Nutritional Structure; MSP: Metabolic Syndrome Predictors; NCD: Non- Communicable Diseases; P: Person; QOL: Quality of Life; QR: Quartile Range; RE: Rating Educations; SNP: SNP Market - Online Store of Electronics and Equipment; SLC6A4: Encodes a Sodium-Dependent Transmembrane Transporter a Neurotransmitter Serotonin Reuptake Protein; TDC: Total Daily Consumption; UN: United Nations; UV: Ultraviolet Level; WHO: World Health Organization