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PhD Department of Physics, University of Rochester (2001) 2001-2004 Postdoctoral Researcher, Chemical Engineering, University of California Berkeley 2004-2012 Assistant Professor, Biomedical Engineering, University of California Davis. 2013-2018 Associate Professor, Computational Biology, Indraprastha Institute of Information Technology, Delhi. 2019 Visiting Professor, Indian Association for the Cultivation of Science, Kolkata
Computational Biology, Biophysics, Systems/Network Biology & Bioengineering, Cell Signalling and Single Cell Biology, Bioinformatics, Condensed Matter Physics & Material Science I apply methods based on kinetic Monte Carlo (stochastic) simulations, Markov chain Monte Carlo (MCMC), theoretical approaches, concept of minimal network, and, statistical data analysis.
Prof. Dr. Alireza Heidari, Ph.D., D.Sc. is a Full Distinguished Professor and Academic Tenure of Chemistry and also Enrico Fermi Distinguished Chair in Molecular Spectroscopy at California South University (CSU), Irvine, California, USA. He has got his Ph.D. and D.Sc. degrees from California South University (CSU), Irvine, California, USA. Furthermore, he has double postdocs in Project Management, Oncology, Human Cancer Tissues and Synchrotron Radiation from Monash University, Melbourne, Victoria, Australia and also in Nanochemistry and Modern Molecular Electronic–Structure Computations Theory from California South University (CSU), Irvine, California, USA. His research interests include Biophysical Chemistry, Biomolecular Spectroscopy, Quantum Chemistry, Nanochemistry, Modern Electronic Structure Computations, Theoretical Chemistry, Mathematical Chemistry, Computational Chemistry, Vibrational Spectroscopy, Molecular Modelling, Ab initio & Density Functional Methods, Molecular Structure, Biochemistry, Molecular Simulation, Pharmaceutical Chemistry, Medicinal Chemistry, Oncology, Synchrotron Radiation, Synchrocyclotron Radiation, LASER, Anti–Cancer Nano Drugs, Nano Drugs Delivery, ATR–FTIR Spectroscopy, Raman Spectroscopy, Intelligent Molecules, Molecular Dynamics, Biosensors, Biomarkers, Molecular Diagnostics, Numerical Chemistry, Nucleic Acids, DNA/RNA Monitoring, DNA/RNA Hypermethylation & Hypomethylation, Human Cancer Tissues, Human Cancer Cells, Tumors, Cancer Tissues, Cancer Cells, etc. He has participated at more than five hundred reputed international conferences, seminars, congresses, symposiums and forums around the world as yet. Also, he possesses many published articles in Science Citation Index (SCI)/International Scientific Indexing (ISI), Medline/PubMed and Scopus Journals. It should be noted that he has visited many universities or scientific and academic research institutes in different countries such as United States, United Kingdom, Canada, Australia, New Zealand, Scotland, Ireland, Netherlands, Belgium, Denmark, Luxembourg, Romania, Greece, Russia, Estonia, Ukraine, Turkey, France, Swiss, Germany, Sweden, Norway, Italy, Austria, Czech Republic, Hungary, Poland, South Africa, Egypt, Brazil, Spain, Portugal, Mexico, Japan, Singapore, Malaysia, Indonesia, Thailand, Taiwan, Hong Kong, South Korea, China, India, Kingdom of Saudi Arabia, Jordan, Qatar, United Arab Emirates, etc. as research fellow, sabbatical and volunteer researcher or visitor and so on heretofore. He has a history of several years of teaching for college students and various disciplines and trends in different universities. Moreover, he has been a senior advisor in various industry and factories. He is expert in many computer programs and programming languages. Hitherto, he has authored more than twenty books and book chapters in different fields of Chemistry. Syne, he has been awarded more than one thousand reputed international awards, prizes, scholarships and honors. Heretofore, he has multiple editorial duties in many reputed international and peer–reviewed journals, books and publishers. Hitherward, he is a member of more than five hundred reputed international academic–scientific–research institutes around the world. It should be noted that he is currently the President of American International Standards Institute (AISI), Irvine, California, USA and also Director of the BioSpectroscopy Core Research Laboratory at California South University (CSU), Irvine, California, USA.
Biophysical Chemistry Biomolecular Spectroscopy Quantum Chemistry Nanochemistry Modern Electronic Structure Computations Theoretical Chemistry Mathematical Chemistry Computational Chemistry Vibrational Spectroscopy Molecular Modelling Ab initio & Density Functional Methods Molecular Structure Biochemistry Molecular Simulation Pharmaceutical Chemistry Medicinal Chemistry Oncology Synchrotron Radiation Synchrocyclotron Radiation LASER Anti–Cancer Nano Drugs Nano Drugs Delivery ATR–FTIR Spectroscopy Raman Spectroscopy Intelligent Molecules Molecular Dynamics Biosensors Biomarkers Molecular Diagnostics Numerical Chemistry Nucleic Acids DNA/RNA Monitoring DNA/RNA Hypermethylation & Hypomethylation Human Cancer Tissues Human Cancer Cells Tumors Cancer Tissues Cancer Cells
Yi Sheng Department of Aging and Geriatric Research 1600 SW Archer Road, Biology of Aging Division Medical Science Building P1-12, Institute on Aging FL32610 University of Florida TN 352-2150025 shengyi@ufl.edu.cn
RESEARCH EXPERIENCE i. Whole genome RNAi screen for the DCV secretion regulators in C. elegans The dense core vesicle (DCV) is a key organelle involved in the secretion of hormones and neuropeptides in endocrine cells and neurons in response to stimulation. However, the mechanisms underlying its biogenesis, trafficking and exocytosis remain largely unknown. In this study, to discover novel players functioning in DCV secretion, we performed a genome-wide RNAi screen in C. elegans by observing worm defecation behavior. A series of genes that function in the intestine to regulate DCV biogenesis or exocytosis were successfully identified. ii. Characterize The CC1-FHA dimer is essential for KIF1A-mediated axonal transport of synaptic vesicles in C. elegans KIF1A, a member of kinesin-3 motors, plays a pivotal role in anterograde axonal transport of synaptic vesicles(SVs). We have shown that the CC1-FHA tandem of KIF1A forms a stable dimer that is crucial for both the dimerization and activation of the motor. However, it remains to be determined whether the CC1-FHA dimer is essential for KIF1A-mediated axonal transport in vivo. Here, the KIF1A-mediated regulation of the locomotion and pumping behavior of C. elegans and exerts a significant impact on KIF1A-mediated axonal SV transport presented in our study, together with previous structural and biochemical studies firmly establish the essential role of the CC1-FHA dimer for KIF1A-mediated neuronal transport. iii. Characterize Syntaxin Opening by the MUN domain Underlies the Function of UNC-13/Munc13s in Synaptic Vesicle Priming UNC-13/Munc13s play a central function in synaptic vesicle priming through their MUN domains. However, it is unclear whether this function arises from the ability of the MUN domain to mediate the transition from the Munc18-1–closed syntaxin-1 complex to the SNARE complex in vitro. Combined with the crystal structure data, mutation of two residues (NF) in the pocket which is highly conserved abrogates synaptic vesicle priming in C. elegans neuromuscular junctions. Here we use the worm behavior assays , electrophysiology technology and optogenetic tools to address this notion that orchestration of syntaxin-1 opening and SNARE complex assembly underlies the central role of UNC-13/Munc13s in synaptic vesicle priming. iiii. Study the diet dependent modulation of healthspan and lifespan in C.elegans. Curriculum Vitae Yi Sheng As a fundamental process present in nearly all species, aging is regulated by both genetics factors and environmental cues. In the past two decades, studies in genetic model organisms have revealed many evolutionarily conserved genes and signaling pathways involved in aging. The aging process is greatly affected by diets. Though different species may consume very different diets, the fundamental principles and basic biological mechanisms underlying dietary perception and food-induced behaviors are highly conserved. We and others have previously shown that C. elegans exhibits distinct behaviors and lifespan on different diets through neuroendocrine signaling and mechanistic Target of Rapamycin Complex 2 (mTORC2). However, the upstream membrane receptor(s) and agonist(s) underlying the diet-induced differential responses still remain elusive (knowledge gap). For the largely conserved principles from C. elegans to human, we hope to conduct these studies may help us understand the molecular mechanisms of diet-triggered feeding behaviors and obesity.
Motorisation and Mobility in Metropolitan areas, Longitudinal Approaches in Travel Behaviour, travel behavior of old people, Forecasting Methods, Equity and distribution effects, Survey Methods
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